Xtreme Everest 2
Large expedition to Everest Base Camp seeking to characterise acclimatisation to environmental hypoxia in Sherpa’s & Westerners to identify biomarkers of (mal-) adaptation that may inspire novel diagnostic/therapeutic targets for the cellular hypoxia seen in critical illness.
- Forearm venous plethysmography
- Nitrate metabolism studies (exhaled, saliva, blood, 24hr urine)
- Ambulatory monitoring (SpO2, NIBP & ECG)
- Core physiological dataset (daily cardiorespiratory observations and symptom-scores)
Supervisors: Prof Mike Grocott & Prof Denny Levett